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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TPP1 All Species: 25.76
Human Site: Y79 Identified Species: 80.95
UniProt: O14773 Number Species: 7
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O14773 NP_000382.3 563 61248 Y79 S S P Q Y G K Y L T L E N V A
Chimpanzee Pan troglodytes Q5IS74 563 61277 Y79 S S P Q Y G K Y L T L E N V A
Rhesus Macaque Macaca mulatta XP_001108748 572 62256 Y88 N S P Q Y G K Y L T L E N V A
Dog Lupus familis XP_855613 563 61316 Y79 G S P H Y G K Y L T L E D V A
Cat Felis silvestris
Mouse Mus musculus O89023 562 61324 Y79 S S P Q Y G K Y L T L E D V A
Rat Rattus norvegicus Q9EQV6 563 61314 Y79 S S P R Y G K Y L T L E D V A
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus
Frog Xenopus laevis NP_001084555 566 62519 F81 D S S Q Y G Q F L S L E E L S
Zebra Danio Brachydanio rerio NP_001122270 557 61520 Y75 D S H Q Y G K Y L S L D E V A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 96.8 89.6 N.A. 88 87.7 N.A. N.A. N.A. 61.1 60.9 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 99.8 97.5 94.3 N.A. 94.8 94.8 N.A. N.A. N.A. 76.8 76.1 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 100 93.3 80 N.A. 93.3 86.6 N.A. N.A. N.A. 46.6 66.6 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 100 100 86.6 N.A. 100 100 N.A. N.A. N.A. 80 80 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 88 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 25 0 0 0 0 0 0 0 0 0 0 13 38 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 0 88 25 0 0 % E
% Phe: 0 0 0 0 0 0 0 13 0 0 0 0 0 0 0 % F
% Gly: 13 0 0 0 0 100 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 13 13 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 88 0 0 0 0 0 0 0 0 % K
% Leu: 0 0 0 0 0 0 0 0 100 0 100 0 0 13 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 13 0 0 0 0 0 0 0 0 0 0 0 38 0 0 % N
% Pro: 0 0 75 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 75 0 0 13 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 13 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 50 100 13 0 0 0 0 0 0 25 0 0 0 0 13 % S
% Thr: 0 0 0 0 0 0 0 0 0 75 0 0 0 0 0 % T
% Val: 0 0 0 0 0 0 0 0 0 0 0 0 0 88 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 100 0 0 88 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _